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Innovative spatial omics technologies
Publications
(1) Zhang D, Deng Y, …, Liu Y, …, Fan R. Spatial epigenome–transcriptome co-profiling of mammalian tissues. Nature, 2023. DOI: 10.1038/s41586-023-05795-1 (2) Liu Y, DiStasio M, …, Fan R. High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology, 2023. https://doi.org/10.1038/s41587-023-01676-0 (3) Deng Y, Bartosovic M, Ma S, Zhang D, Kukanja P, Xiao Y, Su G, Liu Y, …, Fan R. Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level. Nature, 609, 375-383, 2022 (4) Deng Y, Bartosovic M, Kukanja P, Zhang D, Liu Y, .., Fan R. Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level. Science, 2022, 375, 681-686. (5) Franjic D, Skarica M, Ma S, Arellano J, …, Liu Y, Fan R, …, Sestan N. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. doi.org/10.1016/j.neuron.2021.10.036 (6) Liu Y, Yang M, Deng Y, Su G, Enninful A, Guo CC, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R. High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue. Cell, 183, (7) Liu Y, Enninful A, Deng Y, Fan R. Spatial transcriptome sequencing of FFPE tissues at the cellular level. BioRxiv. doi: https://doi.org/10.1101/2020.10.13.338475. Nature Biotechnology (In revision), 2021. (8) Su G, Qin X, Enninful A, Bai Z, Deng Y, Liu Y, Fan R. Spatial multi-omics sequencing for fixed tissue via DBiT-seq. STAR protocols 2 (2), 100532, 2021 (9) Duan Y, Coreas R, Liu Y, Bitounis D, Zhang Z, Parviz D, Strano M, Demokritou P, Zhong W. Prediction of protein corona on nanomaterials by machine learning using novel descriptors. NanoImpact. 2020;17. PMID: 32104746. (10) Liu Y, Gill AD, Duan Y, Perez L, Hooley RJ, Zhong W. A supramolecular sensor array for selective immunoglobulin deficiency analysis. Chemical Communications. 2019;55(77):11563-6. PMID: 31495837. (11) Jiang Q, Liu Y, Wang L, Adkins GB, Zhong W. Rapid Enrichment and Detection of Extracellular Vesicles Enabled by CuS- Enclosed Microgels. Analytical Chemistry. 2019;91(24):15951-8. PMID: 31742386. (12) Gill AD, Perez L, Salinas INQ, Byers SR, Liu Y, Hickey BL, Zhong W, Hooley RJ. Selective Array-Based Sensing of Anabolic Steroids in Aqueous Solution by Host-Guest Reporter Complexes. Chemistry – A Europe Journal. 2019;25(7):1740-5. PMID: 30427566. (13) Fang X, Zheng Y, Duan Y, Liu Y, Zhong W. Recent Advances in Design of Fluorescence-Based Assays for High- Throughput Screening. Analytical Chemistry. 2019;91(1):482-504. PMID: 30481456. (14) Duan Y, Liu Y, Coreas R, Zhong W. Mapping Molecular Structure of Protein Locating on Nanoparticles with Limited Proteolysis. Analytical Chemistry. 2019;91(6):4204-12. PubMed PMID: 30798594. (15) Shen W, Guo K, Adkins GB, Jiang Q, Liu Y, Sedano S, Duan Y, Yan W, Wang SE, Bergersen K, Worth D, Wilson EH, Zhong W. A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity. Angewandte Chemie International Edition. 2018;57(48):15675-80. PMID: 30291794. (16) Liu Y, Wang YM, Sedano S, Jiang Q, Duan Y, Shen W, Jiang JH, Zhong W. Encapsulation of ionic nanoparticles produces reactive oxygen species (ROS)-responsive microgel useful for molecular detection. Chemical Communications. 2018;54(34):4329-32. PMID: 29637948. (17) Liu Y, Lee J, Perez L, Gill AD, Hooley RJ, Zhong W. Selective Sensing of Phosphorylated Peptides and Monitoring Kinase and Phosphatase Activity with a Supramolecular Tandem Assay. Journal of American Chemical Society. 2018;140(42):13869-77. PMID: 30269482. (18) Liu Y, Duan Y, Gill AD, Perez L, Jiang Q, Hooley RJ, Zhong W. Metal-assisted selective recognition of biothiols by a synthetic receptor array. Chemical Communications. 2018;54(93):13147-50. PMID: 30403227. (19) Lee J, Perez L, Liu Y, Wang H, Hooley RJ, Zhong W. Separation of Methylated Histone Peptides via Host-Assisted Capillary Electrophoresis. Analytical Chemistry. 2018;90(3):1881-8. PMID: 29286640. (20) Fang X, Duan Y, Adkins GB, Pan S, Wang H, Liu Y, Zhong W. Highly Efficient Exosome Isolation and Protein Analysis by an Integrated Nanomaterial-Based Platform. Analytical Chemistry. 2018;90(4):2787-95. PMID: 29381333. (21) Liu Y, Perez L, Mettry M, Gill AD, Byers SR, Easley CJ, Bardeen CJ, Zhong W, Hooley RJ. Site selective reading of epigenetic markers by a dual-mode synthetic receptor array. Chemical Science. 2017;8(5):3960-70. PMID: 28553538. (22) Liu Y, Perez L, Gill AD, Mettry M, Li L, Wang Y, Hooley RJ, Zhong W. Site-Selective Sensing of Histone Methylation Enzyme Activity via an Arrayed Supramolecular Tandem Assay. Journal of American Chemical Society. 2017;139(32):10964-7. PMID: 28777546. (23) Liu Y, Mettry M, Gill AD, Perez L, Zhong W, Hooley RJ. Selective Heavy Element Sensing with a Simple Host-Guest Fluorescent Array. Analytical Chemistry. 2017;89(20):11113-21. PMID: 28946741. (24) Fang X, Liu Y, Jimenez L, Duan Y, Adkins GB, Qiao L, Liu B, Zhong W. Rapid Enrichment and Sensitive Detection of Multiple Metal Ions Enabled by Macroporous Graphene Foam. Analytical Chemistry. 2017;89(21):11758-64. PMID: 29034677. (25) Duan Y, Liu Y, Shen W, Zhong W. Fluorescamine Labeling for Assessment of Protein Conformational Change and Binding Affinity in Protein-Nanoparticle Interaction. Analytical Chemistry. 2017;89(22):12160-7. PMID: 29083159. (26) Liu Y, Perez L, Mettry M, Easley CJ, Hooley RJ, Zhong W. Self-Aggregating Deep Cavitand Acts as a Fluorescence Displacement Sensor for Lysine Methylation. Journal of American Chemical Society. 2016;138(34):10746-9. PMID: 27500515. (27) Si F, Liu Y, Yan K, Zhong W. A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals. Chemical Communications. 2015;51(37):7931-4. PMID: 25864583. (28) Liu Y, Ren L, D Yan, Zhong W. Development of microplate-based photoelectrochemical DNA biosensor array for high throughput detection of DNA damage. Sensors and Actuators B: Chemical 161, 334-340 (2012). (29) Liu Y, Jia S, Guo L. Mechanistic Study on the Reduction of SWCNT‐induced Cytotoxicity by Albumin Coating. Particle & Particle Systems Characterization. 2014;31(12):1244-51. PMID: 25580058. (30) Zheng Z, Yuan S, Liu Y, Lu X, Wan J, Wu X, Chen J. Reductive dechlorination of hexachlorobenzene by Cu/Fe bimetal in the presence of nonionic surfactant. Journal of Hazardous Materials. 2009;170(2-3):895-901.PMID: 19545942.
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